Figure 6.

CIN therapy involves the STAT4 pathway. OVA-sensitized BALB/c wild type (WT) and STAT4^-/- knockout mice (n = 4) were given CIN therapy intranasally and challenged with OVA. (A) AHR in response to methacholine was measured one day after the last challenge. The values are means ± SEM (*p < 0.05). (B) Mice were sacrificed the day following AHR measurement and their lungs were removed, paraffin-embedded and stained with hematoxylin/eosin.