Genetic Vaccines and Therapy

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DNA vaccines: designing strategies against parasitic infections

Catherine Ivory and Kris Chadee*

Author Affiliations

Institute of Parasitology of McGill University, Macdonald Campus, 21,111 Lakeshore Road, Ste. Anne de Bellevue, Quebec, Canada, H9X 3V9

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Genetic Vaccines and Therapy 2004, 2:17 doi:10.1186/1479-0556-2-17

Published: 3 December 2004

Abstract

The complexity of parasitic infections requires novel approaches to vaccine design. The versatility of DNA vaccination provides new perspectives. This review discusses the use of prime-boost immunizations, genetic adjuvants, multivalent vaccines and codon optimization for optimal DNA vaccine design against parasites.