Genetic Vaccines and Therapy
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 ResearchSustained protective rabies neutralizing antibody titers after administration of cationic lipid-formulated pDNA vaccineMichal Margalith  and Adrián Vilalta  Vical Incorporated, 10390 Pacific Center Ct, San Diego, CA 92121, USA  author email corresponding author email
Genetic Vaccines and Therapy 2006,
4:2doi:10.1186/1479-0556-4-2
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| Published: |
15 February 2006 |
Abstract
Published data indicate that formulation of pDNA with cationic lipids could greatly enhance the response to a pDNA vaccine in larger mammals. The present work tested the influence of several pDNA:cationic lipid formulations on rabies neutralizing titers. Plasmid expressing Rabies G protein (CVS strain) was evaluated in vivo for ability to elicit neutralizing titers. pDNA:DMRIE-DOPE formulated at two DNA:cationic lipid molar ratios was compared in mice to a Vaxfectin™-pDNA formulation. Mouse data indicate that Vaxfectin™ is more effective than DMRIE-DOPE in eliciting neutralizing titers. In addition, the ratio of pDNA to DMRIE-DOPE can also affect neutralizing titers. Our data show that sustained neutralizing titers (120 days) can be obtained after a single administration of DMRIE-DOPE-formulated pDNA in rabbits. | 
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