Figure 1.

Gene transfer efficiency of the rAAV capsid mutants and control vectors on a panel of leukaemia cell lines (in % GFP⁺ cells) using an MOI of 100. Cell lines: BV173: CML blast crisis (lymphoid); EM3: CML blast crisis relapse; HL60: AML (M2); K562: CML blast crisis (erythroid); KG1a: AML (erythro-leukaemia); Lama84: CML blast crisis. Random = randomly generated capsid mutant rAAV vector. Data are given as mean ± SD (n ≥ 3). * = rAAV capsid mutants significantly (p < 0.001) more efficient than standard rAAV2. ⁺ = as *, but with p < 0.01.