Figure 2.

NPRA knockout prevents allergic airway inflammation. (A) Knockout of NPRA but not NPRC attenuates airway inflammation. C57BL6 wild type, NPRA-/- and NPRC-/- knockout mice were OVA-sensitized (i.p.) at day zero and day seven and challenged twice with OVA (i.n.). Two days later, mice were sacrificed and lung sections were stained with hematoxylin/eosin. (B) BAL fluids were obtained from WT and NPRA-/- mice and assayed by ELISA for pro-inflammatory cytokines, IL-4, -5 and -6. Results shown are averages of two separate experiments with standard deviations (*, P < 0.05, **, P < 0.01).