Figure 2.

Determination of circulating human factor IX levels in blood plasma of AAV8hFIX infused rats. Blood plasma samples from scAAV8-LP1-hFIX infused rats at (black sqaure) 1 × 10¹⁰vg/rat, (black triangle) 5 × 10¹⁰vg/rat, (open triangle) 1 × 10¹¹vg/rat, (open square) 5 × 10¹¹vg/rat or (black circle) saline were assayed by ELISA to measure circulating hFIX activity. All values represent average hFIX levels with standard error of mean. Percentages refer to the percentage of normal circulating FIX levels.