Figure 1.

Sustained High Protective Titers after pDNA vaccination. Two groups of three rabbits were vaccinated with either 1 mg of rabies G protein pDNA VR7203 (Days 1, 28 and 56) (Δ) or with a single administration of IMRAB^® 3 (●) as described in Materials and Methods. pDNA:cationic lipid molar ratio was kept at 4:1. Data points represent individual animal titers. Lines connect mean titer values for each group at each time point. Protective titer threshold (0.5 IU/mL) is indicated with a horizontal line. Vaccination days are indicated with downward arrows.